D Warren Ph.D.
Comparative Genomics Centre,
Molecular Sciences Bldg 21,
James Cook University,
Townsville, 4811, Queensland, Australia
Phone: +61-7-4781-6220 Fax: +61-7-4781-6078
1991-1994 Research Associate, Maryland Biotechnology Institute, Maryland USA
1995-2001 Senior Research Officer, Peter MacCallum Cancer Institute, Melbourne.
2002-present Lecturer, Biochemistry & Molecular. Biology, James Cook University.
Summary of Research Experience:
As a postdoc in the US Warren discovered and cloned the Hermes element, which unlike the Drosophila P element, has a broad host range, and has been shown to be functional in a range of insect species, including Drosophila melanogaster (fruitfly), Lucilia cuprina (blowfly), and Aedes agypti (mosquito). He was awarded a grant from the USDA (with D. O’Brochta) for his work on non-Drosohilid transposable elements, which resulted in six publications and the issuing of a patent (US patient 9,614,398 "A Gene Transfer System for Insects"). In 1995 Warren was appointed to the position of Senior Research Officer at the Peter MacCallum Cancer Institute, Univ. of Melbourne, to study of the epigenetic regulation of human transposable elements, which resulted in 4 publications. In 1998 he commenced his present research focus, currently funded by the ARC, of how higher eukaryotes maintain sister-chromatid cohesion during metaphase. He cloned and characterised the Drosophila rad21 gene (Drad21) and in 2000 publised a paper in Current Biology that reported two additional features of cohesion regulation not previously reported in the literature. His co-discovery of a sub-pool of DRAD21 which does not dissociate from Drosophila chromosomes in prophase but remains at centromeres until anaphase provided the first evidence that cohesins maintain sister-chromatid cohesion until the metaphase-anaphase transition in higher eukaryotes. In addition, his observation that the DRAD21 cohesin subunit transiently associates with centrosomes and either directly or indirectly modulates astral microtubule activity is likely to have a significant impact on the field.