Figure 2a: Section of nodule in the liver of a Bufo marinus showing histiocytes and lymphocytes in a chronic inflammatory response with several foreign body giant cells. The sphaerules of Mucor amphibiorum appear as round bodies with a think, eosinophilic wall. The large giant cell at the bottom right of the image has phagocytosed at least two sphaerules, both of which contain daughter sphaerules. Several other sphareules, some degenerating, occur outside this giant cell to its right. Normal hepatocytes are present in the bottom left corner outlining the edge of the nodule. H&E.
Figure 2b: Sphaerule containing daughter sphaerules in a giant cell in the spleen of a B. marinus. H&E.
Figure 2c: Sphaerule of M. amphibiorum containing daughter sphaerules in a squash preparation from an infected organ of a B. marinus. Unstained. Sphaerules measure 14 to 5 microns in diameter when single and 37 to 15 microns when they contain daughter sphaerules (Speare et al 1994). The daughter sphaerules are released by dissolution of the wall of the mother sphaerule.
