Dr Joseph Moxon

Dr Joseph Moxon

Dr Joseph V Moxon – Senior Research Scientist, Vascular Biology Unit

Supervisor (level 4) for HDR students

Research monitor for the JCU Animal Ethics Committee

Active member of the JCU School of Medicine and Dentistry (SMD) Honours and Research Committees

Med 2 Home Group facilitator

Office

Building 47, Room 109D

Phone

(0061) 07 4781 4109

Fax

(07) 4781 3652

Email

joseph.moxon@jcu.edu.au

Research

My research interest is the identification of potential disease biomarkers using high throughput post-genomic and bioinformatic techniques. Since joining the Vascular Biology Unit in late 2008, I have applied these approaches to further understanding of peripheral artery disease (PAD) using human tissue biopsies and model systems. This has been achieved through the development of robust national, and international collaborations. Recently my work has become more clinically oriented, and I have played a leading role in the establishment of a large biobank comprising blood and tissue samples collected from consenting PAD patients.

I am passionate about highlighting the importance, and relevance of research to the medical profession, and am establishing avenues to enable MBBS students to become involved in scientific research. Notably, I have achieved this goal by successfully mentoring undergraduates in the preparation of competitive grant applications, and supervising resultant laboratory-based projects. As part of the JCU SMD honours and research committees, I am spear-heading initiatives to incorporate critical scientific appraisal within the MBBS curriculum.

Undergraduate and post-graduate research projects are currently available, contact from interested parties is welcomed.

Publications

*Corresponding author; Authors contributed equally; ^Students under my direct supervision

1. Krishna SM, Seto SW, Moxon JV, Rush C, Walker P, Norman P, Golledge J (2012). Fenofibrate increases high density lipoprotein and sphingosine 1 phosphate concentrations limiting abdominal aortic aneurysm progression in a mouse model. The American Journal of Pathology (in press, accepted April 13th 2012).

2. Morris DR,^ Moxon JV, Biros E, Krishna SM, Golledge J (2012). Meta-analysis of the association between transforming growth factor-beta polymorphisms and complications of coronary heart disease. PLoS ONE 7(5): e37878.

3. LaCourse EJ, Perally S, Morphew RM, Moxon JV, Prescott M, Dowling DJ, O’Neill SM, Kipar A, Hetzel U, Hoey E, Zafra R, Buffoni L, Arevalo JP, Brophy PM (2012). The sigma class glutathione transferase from the liver fluke Fasciola hepatica. PLoS Neglected Tropical Diseases 6(5): e1666.

4.Moxon JV,* Emeto TI,^ Golledge J (2012). Further evidence to support a role for urocortin 2 in heart failure. Anadolu Kardiyol Derg 12(2) 121-2. Invited editorial.

5. Moxon JV, Padula MP, Clancy P, Emeto TI,^ Herbert BR, Norman PE, Golledge J (2011). Proteomic analysis of intra-arterial thrombus secretions reveals a negative association of clusterin and thrombospondin-1 with abdominal aortic aneurysm. Atherosclerosis 219(2) 432-9.

6. Biros E, Norman PE, Jones GT, van Rij AM, Yu G, Moxon JV, Blankensteijn JD, van Sterkenburg SM, Morris D,^ Baas AF, Golledge J (2011). Meta-analysis of the association between single nucleotide polymorphisms in TGF-β receptor genes and abdominal aortic aneurysm.

7. Emeto TI,^ Moxon JV, Rush C, Woodward L, Golledge J. (2011). Relevance of urocortins to cardiovascular disease. Journal of Molecular and Cellular Cardiology 51(3) 299-307

8. Trollope A, Moxon JV, Moran CS, Golledge J (2011).Animal models of abdominal aortic aneurysm and their role in furthering management of human disease. Cardiovascular pathology 20(2): 114-23.

9. Moxon JV, Parr A, Emeto TI,^ Walker P, Norman PE, Golledge J (2010). Diagnosis and monitoring of abdominal aortic aneurysm: Current status and future prospects. Current Problems in Cardiology 35(10): 512-48

10.Moxon JV,* LaCourse EJ, Wright HA, Perally S, Prescott MC, Gillard JL, Barrett J, Hamilton JV, Brophy PM (2010). Proteomic analysis of embryonic Fasciola hepatica: Characterization and antigenic potential of a developmentally regulated heat shock protein.Veterinary Parasitology 169: 62-75.

11. Moxon JV,* Flynn RJ, Golden O, Hamilton JV, Mulcahy G, Brophy PM (2010). Immune responses directed at egg proteins during experimental infection with the liver fluke Fasciola hepatica. Parasite Immunology 32: 111-24.

12. Rush C, Nyara M, Moxon JV, Trollope A, Cullen B, Golledge J (2009).Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm. BMC Genomics 10;298.

13. Moxon JV, Padula M, Herbert BR, Golledge J (2009). Challenges, current status and future perspectives of proteomics in improving understanding, diagnosis and treatment of vascular disease. European Journal of Vascular and Endovascular Surgery 38(3): 346-55.

14.Chemale G, Morphew R, Moxon JV, Morassuti AL, LaCourse EJ, Barrett J, Johnston DA, Brophy PM (2006).Proteomic analysis of glutathione transferases from the liver fluke parasite, Fasciola hepatica. Proteomics 6(23): 6263-73.

Grants awarded

1. James Cook University School Administered Internal Grant (SAIG 2012). Lipid Biomarkers for aneurysm disease”. $7,500. JV Moxon and D Liu – Principal Investigator

2. James Cook University School Administered Internal Grant (SAIG 2012). Contribution of ACE2 to human AAA”. $7,500. Y Wang and JV Moxon.

3. James Cook University Competitive Research Incentive Grant (CRIG, 2011). $10,000 - Personal Award following a highly ranked application to the ARC Discovery Early Career Research Award scheme (Round 1 2011 – application was within the top 10-25% of unsuccessful bids)

4. James Cook University Faculty Administered Internal Grant (FAIG 2011). “Stem cell therapy for aortic aneurysms”. $3,000. JV Moxon and J Golledge – Principal Investigator

5. James Cook University Faculty Administered Internal Grant (FAIG, 2010). “Biomarkers of abdominal aortic aneurysm”. $8,000. JV Moxon, AA Mohammed, TI Emeto, J Golledge – Principal Investigator

6. James Cook University Research and Infrastructure Building Grant (RIBG, 2010). “Isoelectric focussing”. $12,500. JV Moxon, S Chora, TI Emeto and J Golledge – Principal Investigator

7. James Cook University Faculty Administered Internal Grant (FAIG, 2009). “Aneurysm proteomics: Biomarker discovery”. $7,650. JV Moxon and J Golledge – Principal Investigator

8. James Cook University Research and Infrastructure Building Grant (RIBG, 2009). “Lab equipment – proteomics analysis”. $12,800. JV Moxon, J Golledge, C Rush, TI Emeto – Principal Investigator

Selected conference presentations

Emeto TI, Moxon JV, Biros E, Clancy P, Moran C, Rush C, Woodward L, Golledge J. Urocortin 2 inhibits human aortic smooth muscle proliferation via corticotrophin releasing hormone receptor-2 in abdominal aortic aneurysm. The 26 th Annual Vascular Research Initiative Conference, Chicago, USA (2012).

Moxon JV, Padula MP, Clancy P, Emeto TI, Herbert BR, Norman PE, Golledge J. Improving the depth of proteomic analysis for biomarker screening studies of complex clinical tissues. The North Queensland Medical Research Symposium, Townsville (2011).

Moxon JV, Padula MP, Herbert BR, Golledge J. Deep-mining the arterial thrombus proteome for diagnostic markers of abdominal aortic aneurysm. Townsville Festival of Life Sciences (2009).

LaCourse J, Perally S, Chemale G, Moxon J, Meaney M, Ward D, Hoey E, Fairweather I, Trudgett A, Brophy P. Triclabendazole response in the liver fluke Fasciola hepatica. Spring meeting of the British Society for Parasitology, Newcastle, UK. (2008).

Moxon JV, Hamilton JV, Brophy PM. Proteomic analysis of Fasciola hepatica eggs and molecular characterisation of liver fluke embryonation.Spring meeting of the British Society for Parasitology, Belfast, UK (2007).

Moxon JV, Hamilton JV, Brophy PM. The egg of Fasciola hepatica: The neglected lifestage. Invited seminar Charles' University, Prague, Czech Republic (2007).

Moxon JV, Hamilton JV, Brophy PM. Probing the Fasciola hepatica proteome for novel diagnostic candidates.The 11th International Congress of Parasitology, Glasgow, UK. (2006).