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Prof Geoffrey Dobson

Geoffrey Dobson

Professor

Phone: (07) 4781 4097

Mobile: (International) +61 407 550 235; (Local) 0407 550 235

Fax: (07) 4781 6279

Room: DB21-121c
Email: geoffrey.dobson@jcu.edu.au

Qualifications

BSc, MSc, PhD

Interests

Current research borrows from natural hibernators and aims to develop new therapeutic strategies to better protect the heart during open-heart surgery, angioplasty, organ transplantation and haemorrhagic shock. Sole inventor on nine international patents.

Founding Director of a biotechnical company developed to raise capital and commercialise these products. For more details see: http://www.adenocaine.com

Author of a book to promote the public understanding of science: "A Chaos of Delight: Science, Religion and Myth and the Shaping of Western Thought". Equinox, London (May 2005).

Reviews
'Geoffrey Dobson's monumental work, A Chaos of Delight, is breathtaking in its daring. It explores the two ways which humanity has used to seek meaning and make sense of the world, namely religion and science. The result is a highly erudite summary of belief systems from early Sumerian to the monotheistic religions; and an eminently accessible history of science, particularly of the last 500 years. The synthesis of these pathways to "provisional truth" works stunningly well.’ Sir Gustav Nossal.

‘Geoffrey Dobson's A Chaos of Delight offers a remarkable panorama of the human understanding of the natural and metaphysical world from the first civilizations to the present day. The book is also noteworthy for its engagement with a vast range of subject matter and for its balanced presentation of religious and scientific knowledge.’ Professor John Baines, The Oriental Institute, University of Oxford.

For more details see http://www.equinoxpub.com/books showbook.asp?bkid=85

Publications

Dobson GP (2010) "Membrane Polarity: A Target for Myocardial Protection and Reduced Inflammation in Adult and Pediatric Cardiothoracic Surgery. Journal Thorac Cardiovasc Surg. (Accepted May 28, 2010) (Editorial – Free Standing).

Letson, H.L and Dobson GP (2010) Small-volume 7.5% NaCl with 6% Dextran-70 or 6% and 10% Hetastarch are associated with arrhythmias and death following 60 min of severe hemorrhagic shock in the rat in vivo. Journal of Trauma, Injury, Infection and Critical Care (Accepted May 25, 2010).

Dobson, GP Vinten Johansen J (2010) Hyperkalemic cardioplegia: the end of an era? Review Article: Eur. J Cardiovasc Surg. In submission.

Sloots KL and Dobson GP (2010) Normokalemic adenosine-lidocaine cardioplegia: importance of maintaining a polarized myocardium for optimal arrest and reanimation, J Thorac Cardiovasc Surg Feb 2. J Thorac Cardiovasc Surg. Jun;139(6):1576–86.

Rudd DM and Dobson GP. (2010) Early reperfusion with warm, polarizing adenosine-lidocaine improves functional recovery following 6 hours of cold static storage J Thorac Cardiovasc Surg. Accepted April 6, 2010.

Rudd DM and Dobson GP. (2009) Towards a new cold and warm non-depolarising normokalemic arrest paradigm for orthotopic heart transplantation J Thorac Cardiovasc Surg. Jan 137: 198–207.

Sloots KL, Vinten-Johansen J, Dobson GP. (2007) Warm non-depolarizing adenosine and lidocaine cardioplegia: continuous versus intermittent delivery. J Thorac Cardiovasc Surg. May;133(5):1171–8.

Vinten-Johansen J, Zhao ZQ, Jiang R, Zatta AJ, Dobson GP. (2007) Preconditioning and postconditioning: innate cardioprotection from ischemia-reperfusion injury. J Appl Physiol. Oct;103(4):1441–8. Epub 2007 Jul 5. Review.

Canyon SJ, and Dobson GP. (2006) The effect of adenosine and lidocaine intravenous infusion on myocardial high-energy phosphates and pH during regional ischemia in the rat model in vivo. Can. J. Physiology and Pharmacology 84(8-9):903–12.

Canyon SJ and Dobson G.P. (2005) Pretreatment with an Adenosine A1 receptor-agonist and Lidocaine: A Possible Alternative to Myocardial Ischemic Preconditioning. J Thoracic and Cardiovascular Surgery, In Press.

Dobson, GP (2004) Organ arrest, Protection and Preservation: Natural Hibernation to Cardiac Surgery. Invited Review. Comp. Biochem. Physiol. Part B 469–485.

Dobson, GP and Jones, M (2004). Adenosine and Lidocaine: A new concept in nondepolarising surgical myocardial arrest, protection and preservation. J Thoracic and Cardiovascular Surgery 127: 794–805.

Canyon SJ and Dobson G.P. (2004) Protection against ventricular arrhythmias and cardiac death using adenosine and lidocaine during regional ischemia in the in vivo rat. American Journal of Physiol 287: H1286–1295.

Dobson, GP (2003) "On Being the Right Size: Heart Design, Mitochondrial Efficiency, and Lifespan potential. A Review Clin. Exp Pharm and Phys 30(8):590–7.

Dobson GP, Hitchins, S and Teague W.E. Jr (2002) �Thermodynamics of the pyruvate kinase reaction and the reversal of glycolysis in heart and skeletal muscle�. J. Biol. Chem. 277 (30) 27176–82.

Dobson GP and Himmelreich, U (2002) Heart Design in mammals: Scaling of ADP and absolute mitochondrial and myofibrillar volumes from mouse to human. Biochemica Biophys. Acta (Bioenergetics) 1553 (3) 72–7.

Hitchins S, Cieslar J and Dobson GP (2001) 31P NMR Quantitation of phosphorus compounds in rat heart and skeletal muscle in vivo. Amer. J. Physiol (Heart & Circul) 281: H882–887.

Himmelreich, U and Dobson GP (2000) Detection and quantification of free cytosolic inorganic phosphate and other phosphorus metabolites in the beating mouse heart. NMR in Biomedicine 13: 1–7.

Teague WE Jr. and Dobson GP (1999) Thermodynamics of the Arginine Kinase reaction. J. Biol. Chem. 274 (32) 22459–63.

Dobson, GP, and Cieslar, JH (1997) Extracellular, Interstitial and plasma spaces in the rat myocardium in vivo. J. Mol. Cell. Cardiol 29 (12) 3357–3363.

Huang, M-T, Huang, S, and Dobson GP (1997) Epinephrine enhances glycogen turnover and depresses glucose uptake in vivo in rat heart. FASEB Journal 11: 973–980.

Dobson, GP (1997) Reshaping the Teaching of Science. A scientist's perspective. J. Chemical Education (Division of American Chemical Society) 74: (4) 453–454.

Dobson, GP and JP Headrick (1995) Bioenergetic Scaling: Metabolic Design and Body-Size Constraints in Mammals. Proc. Natl. Acad. Sci. (USA) 92 (16) 7317–7321.

Golding EM, Teague, WE Jr., and Dobson, GP (1995) Adjustment of K' to varying pH and pMg for the creatine kinase, adenylate kinase, and ATP hydrolysis reactions permitting quantitative cellular bioenergetic assessment. J. Exp. Biol. 198 1775–1782.

Teague, WE Jr, and Dobson, GP (1992) The effect of Temperature on the Creatine Kinase Equilibrium J. Biol. Chem. 267: 14084–14093.

Dobson, GP, Veech RL, Passonneau JV and Huang MT (1990). In Vivo Portal-Hepatic Venous Gradients of Glycogenic Precursors and Incorporation of D-[3-3H] Glucose into Liver Glycogen in the Awake Rat. J. Biol. Chem. 265 (27):16350–16357.

Masuda, T, Dobson GP and Veech RL (1990). The Gibbs-Donnan Near- Equilibrium System of Heart. J. Biol. Chem. 265 (33) 20321–20334.