JCU Events AITHM Seminar: The Parasitic Worm Product Es-62

JCU Events

Wed, 11 Sep 2019

AITHM Seminar: The Parasitic Worm Product Es-62

Townsville, Cairns

When: 11 September 19, 1pm -- 2pm

Where: At James Cook University
Room 202, Building 48 - AITHM, Townsville Campus (via video link)
Room 107, Building B1 - Library, Cairns Campus
Where: Join remotely via zoom: https://jcu.zoom.us/j/777555450

ES-62 is the major secreted protein of the parasitic filarial nematode Acanthocheilonema viteae. We have previously shown ES-62 to be anti-inflammatory by virtue of multiple covalently attached phosphorylcholine (PC) residues and as a consequence, to exhibit protection against disease in certain models of allergic and autoimmune conditions. More recently we have investigated ES-62’s effects in a mouse model of obesity-induced ageing and found it to improve healthspan in both male and female mice and strikingly, to increase lifespan in male mice. Protective effects in the ageing model and also collagen-induced arthritis, a mouse model of rheumatoid arthritis, were found to be associated with changes in the gut microbiome. The protective effects demonstrated by ES-62 dictated that we developed novel, drug-like, PC-based small molecule analogues. These compounds mimic many of ES-62’s protective effects and are currently being considered as a starting point for novel drug development.

Presenter: Prof William Harnett

William Harnett is Professor of Molecular Immunology at the University of Strathclyde, Glasgow, UK. His research career has focused on biochemical, immunological and molecular biological aspects of parasitic helminths and in recent years, his particular interest has been on applying the immunomodulatory molecule ES-62 to the treatment of allergic and autoimmune conditions. This has resulted in generation of ES-62-based drug-like analogues with the aim of developing them as novel therapeutics.

More information: https://www.aithm.jcu.edu.au/aithm-seminar-prof-william-harnett/