AITHM Seminar: Dr Glenn Marsh - CSIRO testing of vaccine efficacy
The CSIRO Australian Centre for Disease Preparedness (ACDP) is a unique facility globally, in particularly for its capabilities at physical containment 4 for animal research, with this recently being conducted at high level of quality oversight. These unique facilities have been utilised extensively, with highlights including the successful testing of vaccine efficacy of a Hendra virus vaccine in horses following challenge with live Hendra virus.
Two examples of the work conducted at ACDP will be discussed during the seminar including the development of a ferret model for Ebola virus and the use of this model for vaccine efficacy testing and transmission studies. The other example will be our more recent work on COVID-19, where we rapidly developed and characterised a ferret model of SARS-CoV-2 infection, which demonstrated shedding of virus from oral and nasal secretions. This model was then rapidly utilised to test several COVID-19 vaccine candidates, demonstrating safety and efficacy in this model. Data generated for at least one of the vaccine candidates has been used to support vaccine licensure.
Attend this seminar live online here.
For more information please click here.