Graduate Research School Available Projects Alternative splicing-based subtyping of 5000 leukaemia and lymphoma samples

Alternative splicing-based subtyping of 5000 leukaemia and lymphoma samples

Title of Project

Alternative splicing-based subtyping of 5000 leukaemia and lymphoma samples

Advisor/s

Dr Ulf Schmitz

College or Research Centre

College of Public Health, Medical & Veterinary Science

Summary of Project

In this project, we will retrieve bulk RNA sequencing data of 5,000 leukaemia/lymphoma patients and perform a comprehensive bioinformatics analysis to confirm known and identify novel molecular disease subtypes based on alternative splicing profiles. Transcriptomics data will be integrated with matched genomics and clinical data. This will enable us to make associations between genomics variants, aberrant splicing events, and clinical outcomes.

Key Words

bioinformatics; multi-omics; leukaemia; lymphoma; single cell; gene regulation; alternative splicing; data analytics

Would suit an applicant who

is interested in cancer biology and large-scale omics data analysis. Some bioinformatics skills (incl. Linux, shell scripting, R programming) would be very helpful.

Updated: 16 Aug 2021