Graduate Research School Available Projects Assessing the role of a carbon monoxide releasing molecule as a signalling molecule involved in the regulation of oxidative and endoplasmic reticulum stress in experimental models of pressure overload-induced cardiac hypertrophy and failure
Assessing the role of a carbon monoxide releasing molecule as a signalling molecule involved in the regulation of oxidative and endoplasmic reticulum stress in experimental models of pressure overload-induced cardiac hypertrophy and failure
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Title of Project
Assessing the role of a carbon monoxide releasing molecule as a signalling molecule involved in the regulation of oxidative and endoplasmic reticulum stress in experimental models of pressure overload-induced cardiac hypertrophy and failure
Advisor/s
Robert Kinobe, Lisa Chilton
College or Research Centre
College of Public Health, Medical & Veterinary Science
Summary of Project
Our previous work as well as the work of other scientists has shown that endogenously produced carbon monoxide and hydrogen sulphide are cell signal transduction molecules with potent antinflammatory and cytoprotective properties. Similarly, a lot of evidence points to an increasing role of neuropeptides such as oxytocin and serotonin in regulating cardiovascular physiology. Our main goal is to assess a potential for clinical application of these endogenously produced gases and neuropeptides as a strategy to mitigate oxidative stress and inflammatory responses that precede chronic heart disease including cardiac hypertrophy and failure, and vascular damage
Key Words
Carbon monoxide; Hydrogen sulphide; hypertension; cardiac failure & therapeutics
Would suit an applicant who
Is intending to do a Masters or PhD
Updated: 07 Apr 2020