Genes regulating liver cancer progression and metabolism

Genes regulating liver cancer progression and metabolism

Advisor/s

A/Prof Lionel Hebbard

College or Research Centre

College of Public Health, Medical & Veterinary Science

Summary of Project

Our focus is to understand the role of novel genes in hepatocellular carcinoma (HCC) progression and metabolism, with the view to develop new therapeutic strategies. The successful applicant will use bioinformatics of public human HCC data sets to determine the association of specific genes in HCC. The function of chosen genes will be determined in mouse and human HCC cell lines using gene ablation techniques and over-expression models. The candidate will learn to perform histology, western blots, genetic analyses and undertake three-dimensional cultures of murine and human liver tumour cells; and use specific small molecule inhibitors to treat HCC in pre-clinical models.

Key Words

bioinformatics; hepatocellular carcinoma; signaling; stem cells; metabolism

Would suit an applicant who

A good science or medical graduate with laboratory experience.

Updated: 23 Feb 2022