Optimal drug combinations to combat regional tuberculosis isolates

Title of Project

Optimal drug combinations to combat regional tuberculosis isolates

Name of Advisor/s

Emma McBryde

College

College of Medicine & Dentistry; Australian Institute of Tropical Health and Medicine

Summary of Project

Drug resistance in Mycobacterium tuberculosis (Mtb) may prove an insurmountable hurdle in TB control. After a decades long wait, new drugs have finally reached the market and these must be used judiciously  in order to prevent resistance emergence and failure of therapy. New data on clinical impact and in vitro efficacy our now available, and these data will be modelled in this project to ascertain the impact of different combinations of anti-mycobacterial agents.

Keywords

• tuberculosis
• infectious diseases
• pharmacokinetics
• pharmacodynamics
• mathematical modelling

Would suit an applicant who

Has a background in mathematics or other quantitative discipline
Has an interest in pharmacology or applying mathematics to a pkpd model
Has an interest in international health