Graduate Research School Available Projects Single-cell multi-omics data analysis to elucidate cell-specific gene isoform regulation in Acute Myeloid Leukemia

Single-cell multi-omics data analysis to elucidate cell-specific gene isoform regulation in Acute Myeloid Leukemia

Title of Project

Single-cell multi-omics data analysis to elucidate cell-specific gene isoform regulation in Acute Myeloid Leukemia

Advisor/s

Dr Ulf Schmitz

College or Research Centre

College of Public Health, Medical & Veterinary Science

Summary of Project

In this project, we will have a comprehensive look into single cell multi-omics data from AML patients. We will dissect  the multiple data layers (genomic, transcriptomic, epigenomic) to analyse the effect of somatic mutations, structural variants, and chromatin accessibility on cancer gene expression and alternative splicing.

Integrative singe-cell multi-omics data analysis methods are sparse and will need to be thoroughly reviewed and possibly customised before they can be applied on this unique dataset.

Key Words

bioinformatics; multi-omics; leukaemia; single cell; gene regulation; alternative splicing; data analytics

Would suit an applicant who

is interested in cancer biology and large-scale omics data analysis. Some bioinformatics skills (incl. Linux, shell scripting, R programming) would be very helpful.

Updated: 16 Aug 2021