Delineating the protective mechanisms against TB induced by mucosal BCG vaccination

Graduate Research School For Candidates Prospective Candidates Available Projects Delineating the protective mechanisms against TB induced by mucosal BCG vaccination

Delineating the protective mechanisms against TB induced by mucosal BCG vaccination

Title of Project

Delineating the protective mechanisms against TB induced by mucosal BCG vaccination

Name of Advisor/s

Dr Andreas Kupz and Professor Natkunam Ketheesan

College

College of Public Health, Medical & Veterinary Science; Australian Institute of Tropical Health and Medicine

Summary of Project

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), continues to cause considerable global morbidity and mortality. This catastrophic situation is largely due to the low efficiency of the only licensed anti-TB vaccine, Bacille Calmette-Gurin (BCG), to afford protection against pulmonary TB and to prevent disease transmission. Therefore, the development and implementation of more efficient vaccines is mandatory if TB is to be eradicated. This study will determine and interrogate the immunological mechanisms that underpin the superior protective effect of mucosal BCG vaccination against Mtb challenge in a mouse model of TB using both in vivo and ex vivo techniques.

Key Words

infectious diseases, tuberculosis, vaccine development, host-pathogen interactions, immune mechanisms

Would suit an applicant who

A graduate who has completed a BSc (Honours) or MSc in areas related to host-pathogen interaction, infectious diseases, immunology or molecular biology