Mechanisms driving TB susceptibility and vaccine efficacy in type-2- diabetes

Graduate Research School For Candidates Prospective Candidates Available Projects Mechanisms driving TB susceptibility and vaccine efficacy in type-2- diabetes

Mechanisms driving TB susceptibility and vaccine efficacy in type-2- diabetes

Title of Project

Mechanisms driving TB susceptibility and vaccine efficacy in type-2- diabetes

Name of Advisor/s

Professor Natkunam Ketheesan, Dr Brenda Govan, Dr Andreas Kupz

College

College of Public Health, Medical & Veterinary Science; Australian Institute of Tropical Health and Medicine

Summary of Project

On a global scale tuberculosis (TB) remains one of the most threatening communicable diseases. Chronic conditions that are immunosuppressive in nature are known to enhance the activation process. Type 2 diabetes (T2D) is a major factor that contributes to this process. It has been shown that TB is 3-7 times more common in patients with T2D. Using a model of diet induced T2D we propose to dissect the primary cell defects that contribute to susceptibility in TB. In human studies we propose to investigate the efficacy of vaccination strategies in T2D with a view to improve vaccine efficacy using adjuvants, metformin and diet.

Key Words

Infectious diseases, tuberculosis, type 2 diabetes, vaccine development, host-pathogen interactions, immune mechanisms

Would suit an applicant who

A graduate who has completed a BSc (Honours) or MSc in areas related to host-pathogen interaction, infectious diseases, immunology or molecular biology