Graduate Research School For Candidates Prospective Candidates Available Projects Metformin to restore defective immune responses in melioidosis patients with diabetes

Metformin to restore defective immune responses in melioidosis patients with diabetes

Title of Project

Metformin to restore defective immune responses in melioidosis patients with diabetes

Name of Advisor/s

Professor Natkunam Ketheesan

College

College of Public Health, Medical & Veterinary Science

Summary of Project

Melioidosis caused by Burkholderia pseudomallei (Bps) is a tropical bacterial infection associated with a high mortality rate. Although individuals with type 2 diabetes (T2D) are most at risk of infection the mechanisms underlying susceptibility to Bps in T2D remain undefined. We will determine if metformin improves inflammatory and immune dysregulation in response to Bps infection in those with T2D. To achieve this, we will utilise our diet induced murine model of T2D. We will also determine the effect of metformin on inflammatory biomarkers and clinical outcome in response to Bps infection. We will conduct the clinical component of the project in patients with and without T2D which will include a Control Cohort and a Post-exposure Cohort.

Key Words

Infectious diseases, melioidosis, type 2 diabetes, host-pathogen interactions, immune mechanisms

Would suit an applicant who

A graduate who has completed a BSc (Honours) or MSc in areas related to host-pathogen interaction, infectious diseases, immunology or molecular biology