Graduate Research School For Candidates Prospective Candidates Available Projects Molecular profiling of host-pathogen interactions in the infectious disease, chytridiomycosis

Molecular profiling of host-pathogen interactions in the infectious disease, chytridiomycosis

Title of Project

Molecular profiling of host-pathogen interactions in the infectious disease, chytridiomycosis

Name of Advisor/s

Alex Roberts, Lee Berger, Lee Skerratt

College

College of Public Health, Medical & Veterinary Science

Summary of Project

Chytridiomycosis is an infectious fungal disease that has caused mass declines and extinctions of amphibians globally. This project will uncover the complex molecular interactions between the host and pathogen. Various molecular biology and analytical techniques, such as protein expression, enzymology, tissue culture, LC-MS and NMR, will be used to characterise immunomodulatory compounds produced during the infection process. You will be part of a world-class multidisciplinary team that includes molecular biologists, epidemiologists, chemists and immunologists. By understanding the virulence and defence mechanisms of this disease system, we can develop new therapeutic targets against the fungus, to help conserve critically endangered amphibians.

Key Words

Fungal pathogen, infectious disease, immune system

Would suit an applicant who

Is interested in molecular biology, infectious diseases, analytical chemistry, animal conservation