Systems biology and/or Bioinformatics of Health and Disease

Title of Project

Systems biology and/or Bioinformatics of Health and Disease

Advisor/s

Dr Ashley Waardenberg, Professor Denise Doolan, Dr Ingrid Wise, Dr Andreas Kupz, Dr Cadhla Firth

College or Research Centre

Australian Institute of Tropical Health and Medicine

Summary of Project

Calling for Systems Biology PhD applications to join the new “Health and Disease” theme of the Centre for Tropical Bioinformatics and Molecular Biology (CTBMB) and Australian Institute of Tropical Health and Medicine (AITHM), at James Cook University (Cairns, Australia). Bioinformatics and Systems Biology projects opportunities exist in a range of infectious and chronic diseases that affect the tropics, such as tuberculosis, malaria, dengue, and diabetes as well as ongoing national and international collaborations in neuroscience and malaria. Systems Biology aims to better understand human disease using a combination of high-throughput technology (such as DNA/RNA sequencing, proteomics etc.) and bioinformatics. Projects are available in pure bioinformatics/systems biology, utilising and developing bioinformatics/systems biology/statistics/machine learning methods as well as joint wet-lab/dry-lab projects through excellent cross-cutting co-supervision. Specific project opportunities exist for: - Development of bioinformatics methods for untangling disruptive signalling in neurological disease (collaboration with Dr Mark Graham; Children’s Medical Research Institute) - Establishment of host-pathogen interaction bioinformatics platforms and methods for simultaneous analysis of host and pathogen transcriptomics (collaboration opportunities with Prof Doolan, Dr Wise and Dr Firth) - Multi-omics bioinformatics of BCG vaccinated and Mtb-infected children (collaboration with Dr Kuptz, TB Immunology Group) Please contact ASAP to discuss project opportunities.

Key Words

Malaria; tuberculosis; neuroscience; bioinformatics; immunology; vaccine; multi-omics; host-pathogen interaction; R; statistics; sequencing technology

Would suit an applicant who

PhD candidate interested in bioinformatics and systems biology approaches to understanding disease.

Updated: 2 months ago