The Role of TLR in the Regulation of the Microbiome, Gut Integrity and Autoimmunity
Title of Project
The Role of TLR in the Regulation of the Microbiome, Gut Integrity and Autoimmunity
Name of Advisor/s
Dr Margaret Jordan, Professor Alan Baxter
College
College of Public Health, Medical & Veterinary Sciences
Summary of Project
Type 1 diabetes accounts for >90% of diabetes in children under 14 years. Children with diabetes have altered intestinal immune responses, changes in the bacteria in their guts, and increased leakiness of the intestines. We have found that the genetic deletion of some genes that are involved in the immune recognition of bacteria from mice has replicated these problems and increased the risk of developing diabetes. This provides us with the perfect opportunity to work out how these problems are related, and how they cause diabetes.
Key Words
Immunology, Genetics, Cellular Immunology, Cell-mediated immunity, Cellular immunology, Molecular Autoimmunity, Immunogenetics, Mouse models, Microbiome, T1D, Type 1 Diabetes.
Would suit an applicant who
Knowledge of immunology and experience with histology, tissue culture and/or immunological techniques. Has experience with statistical analyses and/or bioinformatics.
