QRC-PVD Clinical Trial - Metformin for Treating Peripheral Artery Disease-Related Walking Impairment (MERIT)

Peripheral Artery Disease (PAD) is a blockage and narrowing of arteries which leads to poor circulation in the legs. This reduces the ability of patients to undertake physical activity which reduces quality of life. There are no current effective treatments to manage PAD other than surgery. Surgery is the most common way to improve circulation however it is expensive and can have complications.

A number of research studies suggest a drug called Metformin may improve patients' physical activity. The drug is approved by the Australian Therapeutics Goods Administration and is well tolerated and safe for participants who do not have diabetes. Research suggests that Metformin may:

  • Encourage new blood vessels to form
  • Improve muscle function, and
  • Improve pain tolerance.

Recruitment Status

Not yet recruiting

Ethics Approval

Human Research Ethics Approval
HERC/18/QTHS/159

What's involved

Participants will be given medications to take however, half of the participants will be taking the real medication (metformin) and half will be taking a dummy medication (placebo). Neither you nor the researchers will know which one you’re taking. The aim of the study will be to see whether there is a change in walking distance after six months of taking the medication.

Taking part in this study will involve completing questionnaires, a physical assessment and physical tests, as well as blood sampling. There will be no costs associated with your participation in the research and this is not a paid research activity.

What you can expect

Initial visit

Health check-up:

  • Blood pressure test of your legs
  • 6 minute walking test
  • Activity monitor fitted
  • Blood test and collection

1-2 hours

Second visitRemoval of activity monitor and questionnaires1-2 hours
Week 1Phone call with research team10-15 minutes
Week 2Phone call with research team10-15 minutes
Week 3Phone call with research team10-15 minutes
Week 4Phone call with research team10-15 minutes
Week 5Phone call with research team10-15 minutes
Week 6Phone call with research team10-15 minutes
Week 10Phone call with research team10-15 minutes
Week 20Phone call with research team10-15 minutes
Week 30

Health check-up:

  • Blood pressure test of your legs
  • 6 minute walking test
  • Activity monitor fitted
  • Bood test and collection

1-2 hours

Week 31

Removal of activity monitor and questionnaires

1-2 hours

How to participate

Register your interest in participating in this study.