QRC-PVD Research Team
Professor Jonathan Golledge
Professor Jonathan Golledge is Director of the QRC-PVD and its pre-clinical arm The Vascular Biology Unit (VBU) at the College of Medicine and Dentistry, James Cook University. He joined JCU in 2002 and established the QRC-PVD with the aim of carrying out research intended to be translated into improved management of peripheral vascular diseases.
Dr Corey Moran
Senior Research Scientist
Dr Corey Moran has 12 years' postdoctoral research experience in the field of vascular biology, with scientific training to date geared to develop a solid research foundation in artery disease. He received his PhD from James Cook University in 2006 and undertook consecutive postdoctoral appointments within the JCU Vascular Biology Unit after winning the National Heart Foundation of Australia’s John Shaw and the Queensland Government Smart Futures fellowships. Corey continues as a Senior Research Scientist (pre-clinical) within the QRC-PVD with a research focus on understanding pathological weakening of the human aorta, identifying potential drug-based intervention strategies, and in vivo drug delivery systems for the treatment of abdominal aortic aneurysm (AAA). A developing area of interest for Corey is the role of mitochondrial dysfunction in accelerated senescence and impaired growth of vascular smooth muscle cells associated with aortic wall degeneration, and can how this can be targeted as early intervention to limit expansion of small AAA.
Dr Joseph Moxon
Senior Research Scientist
Joseph's research focus is on PAD, predominately complications arising from lower limb atherosclerosis and abdominal aortic aneurysm. Upon joining JCU, he was surprised to learn how common PAD is within the general population. Approximately one quarter of the adult population will develop PAD and this significantly increases the risk of suffering major cardiovascular events (such as heart attack) and increases the rate of functional decline. Despite this, there are no effective drugs to treat patients, many of whom will ultimately require invasive surgery to treat their condition. Joseph's research primarily focuses on identifying novel drug or diagnostic targets for PAD with a specific emphasis on translating findings from the laboratory to the patient.
Dr Smriti Krishna
Senior Research Scientist
Smriti leads one of the QRC-PVD pre-clinical teams with a special focus on development and use of pre-clinical models of blocked arteries (peripheral arterial diseases; PAD) and weakened arteries (abdominal aortic aneurysms; AAA).
Dr Pacific Huynh
Freshly arrived from a PhD at the Department of Diabetes, Monash University in Victoria, Dr Pacific Huynh's research is focused on the pathological role of a profibrotic molecule, Cell Division Autoantigen-1, in the context of renal fibrosis. In the course of his studies at Monash, he utilised a number of mouse models of non-diabetic and diabetic renal fibrosis, as well as a vast repertoire of biochemical techniques.Pacific joined the JCU Vascular Biology Unit mid-2018 to conduct functional and biochemical research in mouse models of vascular disease, in particular diabetes-associated peripheral wound healing and abdominal aortic aneurysms.
Dr Rene Jaeggi
Clinical Trial Manager
Rene has a background in research, R&D, drug development, project and clinical trial management with a PhD in Biochemistry. In his current role at JCU, Rene manages all aspects of multi-centre clinical trials in the indication of peripheral vascular disease.
Junior Research Fellow
Vikram is a Vascular Surgery Registrar based at the Royal Brisbane & Women's Hospital, having returned there after two years in Townsville as an Academic Registrar in Vascular Surgery. He is currently investigating DNA variations in AAA and PAD compared to healthy controls, as well as looking at the role of circulating miRNAs in AAA development and growth and their use as prognostic biomarkers. He is also involved in a project assessing peak wall stress in ruptured and intact AAA through software analysis of CT scans in collaboration with the KTH Royal Institute of Technology in Sweden. Vikram's other research interests are medical management of AAA and PAD and the molecular basis for AAA and PAD progression.
Senior Clinical Research Worker and Team Leader
Jenna is an accredited exercise physiologist with experience in conducting clinical research, in particular clinical trials. Her current role is to set up and coordinate QRC-PVD clinical trials. Jenna is also a sessional lecturer for the degree of exercise physiology for JCU Sport and Exercise Science.
Senior Clinical Research Worker
Lisan recruits, coordinates and assesses participants for the Brief Behavioural Counselling Intervention for Peripheral Artery Disease (BIP). She is also involved with two other pharmaceutical trials, FAME2 and TEDY, which investigates different drug treatments for Abdominal Aortic Aneurysm (AAA).
Lisan uses dietetic experience and skills to conduct dietary assessments on patients with peripheral vascular disease. The role of nutrition in this condition is not well understood and she aims to further increase knowledge in this area so that a greater understanding can be achieved and a dietary treatment can be developed.
Clinical Research Worker
Cindy oversees ethics and governance requirements for all clinical trials. She also coordinates and provides interventions within the Brief Behavioural Counselling Intervention for Peripheral Artery Disease (BIP) study.
Glenys previously worked as a registered nurse (RN), training at the Townsville Hospital in 1991, followed by postgraduate work as a qualified RN for the next 15 years. After leaving nursing, she operated her own business. Glenys commenced with the QRC-PVD in 2011 to assist with data collection and patient information management.