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QRC-PVD Clinical Trial - Inositol in the Management of Abdominal Aortic Aneurysm (IMAGEN)
This study aimed to test the effectiveness of a dietary supplement, Inositol, in reducing the growth of small (30mm or over) abdominal aortic aneurysms (AAA). Inositol is a dietary supplement which appeared to slow growth of AAA in laboratory experiments.
IMAGEN was a double blind study, which means neither the research team or the participants were aware of who received the dietary supplement and who received the placebo.
The only treatment available for AAA is surgical repair. Surgery is associated with a number of complications and is only performed on patients who have a high risk of bursting their AAA. Patients with small AAA (measuring below 5cm) are simply monitored by regular scans to measure the growth of the AAA over time. Abdominal aortic aneurysms slowly grow over time; at the commencement of this study there were no current treatments which slowed their growth.
Consenting participants attended our study centres a minimum of four times over 12 months. Seventy-five participants took part in this study which took place over three years.
The data collected from this study is still being analysed. Results will be published in peer-reviewed journal articles and communicated to participants.
Rowbotham, S.E., et al. (2017) Inositol in the MAnaGemENt of abdominal aortic aneurysm (IMAGEN): study protocol for a randomised controlled trial. Trials, 18:547 [doi:10.1186/s13063-017-2304-x]