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Graduate Research School Available Projects Portable long-read sequencing to diagnose Chronic Kidney Disease

Portable long-read sequencing to diagnose Chronic Kidney Disease

Title of Project

Portable long-read sequencing to diagnose Chronic Kidney Disease

Advisor/s

A/Prof Ulf Schmitz

College or Research Centre

College of Public Health, Medical & Veterinary Science

Summary of Project

This project addresses the early diagnosis of genetic predispositions for Chronic Kidney Disease (CKD), which poses an increasing burden on the North Queensland population and unequally affects the Indigenous Australian peoples. We will develop a mobile diagnostic pipeline that allows a rapid and cost-efficient screening for genetic CKD predispositions using a targeted long-read sequencing approach.

We will use a computer-aided adaptive sequencing approach (ReadUntil) based on known disease-causing genes. This pilot project will determine the suitability of portable 3rd generation sequencing methods to diagnose CKD in remote communities.

Key Words

bioinformatics; long-read sequencing; genetic testing; chronic kidney disease

Would suit an applicant who

is interested in hereditary disease diagnostic and long-read sequencing data analysis. Some bioinformatics skills (incl. Linux, shell scripting, R programming) would be very helpful.

Updated: 25 Feb 2022