Harnessing the power of T cells for improved treatment outcomes for respiratory infectious diseases

Harnessing the power of T cells for improved treatment outcomes for respiratory infectious diseases

Advisor/s

A/Prof Ulf Schmitz, Dr Daniel Xing, Prof Andreas Lopata

College or Research Centre

College of Medicine & Dentistry; College of Public Health, Medical & Veterinary Science

Summary of Project

Join our dynamic research team at JCU and the Townsville Cancer Centre (TCC) for an exciting HDR (Higher Degree by Research) project that merges cutting-edge technology with critical clinical applications. Our umbrella project encompasses two groundbreaking research initiatives aimed at improving cancer treatment outcomes and patient care. Project 1: Enhancing Glioblastoma Treatment with Magnetic Resonance and Radiotherapy Glioblastoma (GBM) remains one of the most aggressive brain cancers, with limited survival rates despite recent advances in treatment. Our research focuses on the novel application of tumour treating fields and the integration of a magnetic resonance linear accelerator (MRL) to explore the biological effects of combining magnetic fields with ionizing radiation. We aim to uncover how these combined modalities impact tumour and immune cell interactions, ultimately seeking to improve GBM treatment efficacy. Project 2: Developing Blood-Based Surveillance for HPV-Associated Oropharyngeal Cancer Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (HPV-OPSCC) presents unique challenges in post-treatment surveillance, particularly for patients in remote regions. Our research aims to develop and validate a blood-based circulating HPV-DNA (cHPV-DNA) test using next-generation sequencing (NGS). This innovative approach will enable earlier detection of recurrent disease, reduce patient burden, and improve survival outcomes for HPV-OPSCC patients.

Between 2000-2018, the most common cause of death and hospitalisation in Australia was from respiratory infections. These numbers will increase due to the Covid-19 pandemic. Despite expensive treatments and painful procedures including antibiotics, antivirals, intubation, mechanical ventilation etc the mortality rate remain high. Survivors suffer from lung damage that leads to poor quality of life, sometimes for up to 10 years. This project will focus on a new treatment based on lymphocyte delivery to the lung to help individuals recover faster and reduce hospitalisation and death among the elderly, infants and those with chronic medical conditions.

Key Words

brain cancer; head and neck cancer; radiation oncology; biomarker; bioinformatics next generation sequencing

Would suit an applicant who

We invite motivated students with a passion for oncology, molecular biology, and innovative technology to apply. This is a unique opportunity to contribute to transformative research with the potential to significantly impact patient care and treatment outcomes.

has a background in immunology, infectious diseases or related areas of biological sciences.

Updated: 17 May 2022