Assessing the role of a carbon monoxide releasing molecule as a signalling molecule involved in the regulation of oxidative and endoplasmic reticulum stress in experimental models of pressure overload-induced cardiac hypertrophy and failure

Graduate Research School For Candidates Prospective Candidates Available Projects Assessing the role of a carbon monoxide releasing molecule as a signalling molecule involved in the regulation of oxidative and endoplasmic reticulum stress in experimental models of pressure overload-induced cardiac hypertrophy and failure

Assessing the role of a carbon monoxide releasing molecule as a signalling molecule involved in the regulation of oxidative and endoplasmic reticulum stress in experimental models of pressure overload-induced cardiac hypertrophy and failure

Title of Project

Assessing the role of a carbon monoxide releasing molecule as a signalling molecule involved in the regulation of oxidative and endoplasmic reticulum stress in experimental models of pressure overload-induced cardiac hypertrophy and failure

Name of Advisor/s

Dr Robert Kinobe & Dr Lisa Chilton

College

College of Public Health, Medical & Veterinary Science

Summary of Project

Our previous work as well as the work of other scientists has shown that endogenously produced carbon monoxide and hydrogen sulphide are cell signal transduction molecules with potent antiinflammatory and cytoprotective properties. Similarly, a lot of evidence points to an increasing role of neuropeptides such as oxytocin and serotonin in regulating cardiovascular physiology. Our main goal is to assess a potential for clinical application of these endogenously produced gases and neuropeptides as a strategy to mitigate oxidative stress and inflammatory responses that precede chronic heart disease including cardiac hypertrophy and failure, and vascular damage

Key Words

Carbon monoxide, Hydrogen sulphide, Hypertension, Cardiac Failure & Therapeutics

Would suit an applicant who

Is intending to register for an MSc or PhD