Assessment of renal function in neonates and infants using Cystatin C

Graduate Research School For Candidates Prospective Candidates Available Projects Assessment of renal function in neonates and infants using Cystatin C

Assessment of renal function in neonates and infants using Cystatin C

Title of Project

Assessment of renal function in neonates and infants using Cystatin C

Name of Advisor/s

Donna Rudd and Yoga Kandasamy

College

College of Public Health, Medical & Veterinary Science

Summary of Project

Serum creatinine measurement has been used to determine glomerular filtration rate (GFR) in both adults, children and neonates. However, creatinine measurement is associated with many pitfalls.  Serum creatinine level only starts to rise once the GFR falls below 50%, dependent on muscle mass and in babies, levels in the first few days of life reflect maternal serum creatinine level. Cystatin C is increasing being recognized as a more reliable biomarker of renal function. This study aims to undertake a clinical trial involving the NICU, PICU and paediatrics units at TTH, to explore and implement the use of Cystatin C into clinical practice.

Key Words

Renal function, creatinine, GFR, eGFR, neonates, paediatrics, biomarkers

Would suit an applicant who

This study would suit a PhD applicant with a Biomedical Science or Medical Laboratory Science degree. Medical students are welcome, however, the project may involve laboratory work