Graduate Research School Available Projects Metabolic Control of Innate and Innate-Like Immunity
Metabolic Control of Innate and Innate-Like Immunity
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Title of Project
Metabolic Control of Innate and Innate-Like Immunity
Advisor/s
Margaret Jordan, Alan Baxter
College or Research Centre
College of Public Health, Medical & Veterinary Science
Summary of Project
NKT cells respond to glycolipids and play a critical role in controlling the strength and character of immune responses. Their numbers in humans are highly variable and their numbers and function correlate with immunity in heath, cancer, infection and autoimmunity.This project will examine the molecular mechanism by which innate-like T cells are affected by lipid metabolism and aims to identify a novel control point by which the immune system can be manipulated, for which many therapeutics already exist
Key Words
Immunology; cell killing; cell-mediated immunity; natural killer cells; molecular autoimmunity; immunogenetics; mouse models
Would suit an applicant who
Has knowledge of immunology and/or metabolism and experience with molecular biology techniques, flow cytometry and/or tissue culture techniques. Is familiar with statistical analyses.
Updated: 07 Apr 2020